3K35

Crystal Structure of Human SIRT6

Summary for 3K35

Entry DOI	10.2210/pdb3k35/pdb
Descriptor	NAD-dependent deacetylase sirtuin-6, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE, ... (6 entities in total)
Functional Keywords	rossmann fold, zn-binding domain, structural genomics, structural genomics consortium, sgc, adp-ribosylation, metal-binding, nad, nadp, nucleus, phosphoprotein, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm : Q8N6T7
Total number of polymer chains	6
Total formula weight	215880.60
Authors	Pan, P.W.,Dong, A.,Qiu, W.,Loppnau, P.,Wang, J.,Ravichandran, M.,Bochkarev, A.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Min, J.,Edwards, A.M.,Structural Genomics Consortium (SGC) (deposition date: 2009-10-01, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Pan, P.W.,Feldman, J.L.,Devries, M.K.,Dong, A.,Edwards, A.M.,Denu, J.M. Structure and biochemical functions of SIRT6. J.Biol.Chem., 286:14575-14587, 2011 Cited by PubMed: 21362626 DOI: 10.1074/jbc.M111.218990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation