3K2H

Co-crystal structure of dihydrofolate reductase/thymidylate synthase from Babesia bovis with dUMP, Pemetrexed and NADP

Summary for 3K2H

• Entry DOI: 10.2210/pdb3k2h/pdb
• Related: 3i3r
• Descriptor: Dihydrofolate reductase/thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... (6 entities in total)
• Functional Keywords: niaid, ssgcid, seattle structural genomics center for infectious disease, alimta, folic acid analog, thya, folate antimetabolites, tic-borne parasitic protozoan, babesiosis, malaria-like disease, methyltransferase, transferase
• Biological source: Babesia bovis
• Total number of polymer chains: 2
• Total formula weight: 120690.47

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-09-30, release date: 2009-10-13, Last modification date: 2023-09-06)

• Primary citation: Begley, D.W.,Edwards, T.E.,Raymond, A.C.,Smith, E.R.,Hartley, R.C.,Abendroth, J.,Sankaran, B.,Lorimer, D.D.,Myler, P.J.,Staker, B.L.,Stewart, L.J.; Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.; Acta Crystallogr.,Sect.F, 67:1070-1077, 2011; PubMed: 21904052; DOI: 10.1107/S1744309111029009

Experimental method

X-RAY DIFFRACTION (2.2 Å)