3K2F

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

3K2F の概要

• エントリーDOI: 10.2210/pdb3k2f/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, no-donating agent, antiglaucoma drug, sulfonamide, xray crystallography, lyase, acetylation, cytoplasm, disease mutation, metal-binding, polymorphism, zinc
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30087.58

構造登録者

Temperini, C.,Cecchi, A. (登録日: 2009-09-30, 公開日: 2009-11-17, 最終更新日: 2023-11-01)

• 主引用文献: Steele, R.M.,Benedini, F.,Biondi, S.,Borghi, V.,Carzaniga, L.,Impagnatiello, F.,Miglietta, D.,Chong, W.K.,Rajapakse, R.,Cecchi, A.,Temperini, C.,Supuran, C.T.; Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma; Bioorg.Med.Chem.Lett., 19:6565-6570, 2009; PubMed: 19854054; DOI: 10.1016/j.bmcl.2009.10.036

実験手法

X-RAY DIFFRACTION (1.98 Å)