3K1W

New Classes of Potent and Bioavailable Human Renin Inhibitors

3K1W の概要

• エントリーDOI: 10.2210/pdb3k1w/pdb
• 分子名称: Renin, 4-{4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl}-N-(2-chlorobenzyl)-N-cyclopropyl-1,2,5,6-tetrahydropyridine-3-carboxamide, FORMIC ACID, ... (7 entities in total)
• 機能のキーワード: renin, protease, alternative splicing, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, secreted, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P00797
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76576.11

構造登録者

Prade, L. (登録日: 2009-09-29, 公開日: 2010-03-02, 最終更新日: 2024-11-20)

主引用文献

Remen, L.,Bezencon, O.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Corminboeuf, O.,Boss, C.,Grisostomi, C.,Sifferlen, T.,Strickner, P.,Hess, P.,Delahaye, S.,Treiber, A.,Weller, T.,Binkert, C.,Steiner, B.,Fischli, W.
New classes of potent and bioavailable human renin inhibitors
Bioorg.Med.Chem.Lett., 19:6762-6765, 2009

PubMed Abstract: New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The synthesis of these new types of mono- and bicyclic scaffolds are reported, and properties of selected compounds discussed.

PubMed: 19853442
DOI: 10.1016/j.bmcl.2009.09.104

実験手法

X-RAY DIFFRACTION (1.5 Å)