3K15

Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus

3K15 の概要

• エントリーDOI: 10.2210/pdb3k15/pdb
• 関連するPDBエントリー: 3K05 3K0H 3K0K 3K15
• 分子名称: Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: brca1, brct domain, dna damage response, phospho peptide interactions, bach1, alternative initiation, cell cycle, disease mutation, dna damage, dna repair, dna-binding, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, nucleus, phosphoprotein, tumor suppressor, ubl conjugation pathway, zinc-finger, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25271.07

構造登録者

Campbell, S.J.,Edwards, R.A.,Glover, J.N. (登録日: 2009-09-25, 公開日: 2010-03-02, 最終更新日: 2021-10-13)

• 主引用文献: Campbell, S.J.,Edwards, R.A.,Glover, J.N.; Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1; Structure, 18:167-176, 2010; PubMed: 20159462; DOI: 10.1016/j.str.2009.12.008

実験手法

X-RAY DIFFRACTION (2.8 Å)