3JZI
Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series
Summary for 3JZI
Entry DOI | 10.2210/pdb3jzi/pdb |
Related | 3JZF |
Descriptor | Biotin carboxylase, 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide (3 entities in total) |
Functional Keywords | biotin carboxylase; accc; acetyl coenzyme-a carboxylase; accase;, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, nucleotide-binding |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 107898.03 |
Authors | Cheng, C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. (deposition date: 2009-09-23, release date: 2009-11-03, Last modification date: 2023-09-06) |
Primary citation | Cheng, C.C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.A.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19:6507-6514, 2009 Cited by PubMed: 19875284DOI: 10.1016/j.bmcl.2009.10.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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