3JZI

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

3JZI の概要

関連するPDBエントリー3JZF
分子名称Biotin carboxylase, 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide (3 entities in total)
機能のキーワードbiotin carboxylase; accc; acetyl coenzyme-a carboxylase; accase;, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, nucleotide-binding
由来する生物種Escherichia coli
ポリマー鎖数2
分子量合計107898.03
構造登録者
Cheng, C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. (登録日: 2009-09-23, 公開日: 2009-11-03, 最終更新日: 2011-07-13)
主引用文献
Cheng, C.C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.A.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T.
Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19:6507-6514, 2009
PubMed: 19875284 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2009.10.057
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.31 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.220201.8%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 3jzi
回転なし
Molmil generated image of 3jzi
x軸(左右方向)周りに90°回転
Molmil generated image of 3jzi
y軸(上下方向)周りに90°回転