3JZI

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

3JZI の概要

• エントリーDOI: 10.2210/pdb3jzi/pdb
• 関連するPDBエントリー: 3JZF
• 分子名称: Biotin carboxylase, 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide (3 entities in total)
• 機能のキーワード: biotin carboxylase; accc; acetyl coenzyme-a carboxylase; accase;, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, nucleotide-binding
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107898.03

構造登録者

Cheng, C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. (登録日: 2009-09-23, 公開日: 2009-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Cheng, C.C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.A.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T.; Discovery and optimization of antibacterial AccC inhibitors.; Bioorg.Med.Chem.Lett., 19:6507-6514, 2009; PubMed: 19875284; DOI: 10.1016/j.bmcl.2009.10.057

実験手法

X-RAY DIFFRACTION (2.31 Å)