3JZB

Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC

Summary for 3JZB

Entry DOI	10.2210/pdb3jzb/pdb
Related	3JZC
Descriptor	THRA protein, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID (3 entities in total)
Functional Keywords	triac, tr, thyroid, entropy, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31399.88
Authors	Nascimento, A.S.,Dias, S.M.G.,Nunes, F.M.,Aparicio, R. (deposition date: 2009-09-23, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Martinez, L.,Nascimento, A.S.,Nunes, F.M.,Phillips, K.,Aparicio, R.,Dias, S.M.,Figueira, A.C.,Lin, J.H.,Nguyen, P.,Apriletti, J.W.,Neves, F.A.,Baxter, J.D.,Webb, P.,Skaf, M.S.,Polikarpov, I. Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc.Natl.Acad.Sci.USA, 106:20717-20722, 2009 Cited by PubMed: 19926848 DOI: 10.1073/pnas.0911024106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.007 Å)

Structure validation