3JW2

HIV-1 Protease Mutant G86S with DARUNAVIR

3JW2 の概要

• エントリーDOI: 10.2210/pdb3jw2/pdb
• 関連するPDBエントリー: 2IEN 3JVW 3JVY
• 分子名称: Gag-Pol polyprotein, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hiv-1 protease, mutant g86s, inhibitor, darunavir, aids, aspartyl protease, metal-binding, hydrolase
• 由来する生物種: Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22147.51

構造登録者

Tie, Y.,Weber, I.T. (登録日: 2009-09-17, 公開日: 2009-12-08, 最終更新日: 2023-09-06)

• 主引用文献: Ishima, R.,Gong, Q.,Tie, Y.,Weber, I.T.,Louis, J.M.; Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease; Proteins, 78:1015-1025, 2009; PubMed: 19899162; DOI: 10.1002/prot.22625

実験手法

X-RAY DIFFRACTION (1.8 Å)