3JVS

Characterization of the Chk1 allosteric inhibitor binding site

3JVS の概要

• エントリーDOI: 10.2210/pdb3jvs/pdb
• 関連するPDBエントリー: 3JVR
• 分子名称: Serine/threonine-protein kinase Chk1, 2-[(4-tert-butyl-3-nitrophenyl)carbonyl]-N-naphthalen-1-ylhydrazinecarboxamide (3 entities in total)
• 機能のキーワード: protein kinase, atp-binding, cell cycle, cytoplasm, dna damage, dna repair, isopeptide bond, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, ubl conjugation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31661.41

構造登録者

Chen, P. (登録日: 2009-09-17, 公開日: 2009-10-06, 最終更新日: 2024-02-21)

• 主引用文献: Vanderpool, D.,Johnson, T.O.,Ping, C.,Bergqvist, S.,Alton, G.,Phonephaly, S.,Rui, E.,Luo, C.,Deng, Y.L.,Grant, S.,Quenzer, T.,Margosiak, S.,Register, J.,Brown, E.,Ermolieff, J.; Characterization of the CHK1 allosteric inhibitor binding site.; Biochemistry, 48:9823-9830, 2009; PubMed: 19743875; DOI: 10.1021/bi900258v

実験手法

X-RAY DIFFRACTION (1.9 Å)