3JUT
Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid
Summary for 3JUT
Entry DOI | 10.2210/pdb3jut/pdb |
Related | 3K1X |
Descriptor | Heparin-binding growth factor 1, 2,5-dihydroxybenzoic acid (3 entities in total) |
Functional Keywords | growth factor, fgf-1 inhibitors, angiogenesis, developmental protein, differentiation, heparin-binding, mitogen, hormone |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P05230 |
Total number of polymer chains | 6 |
Total formula weight | 88824.46 |
Authors | Fernandez, I.S.,Gimenez-Gallego, G.,Romero, A. (deposition date: 2009-09-15, release date: 2010-02-02, Last modification date: 2023-11-01) |
Primary citation | Fernandez, I.S.,Cuevas, P.,Angulo, J.,Lopez-Navajas, P.,Canales-Mayordomo, A.,Gonzalez-Corrochano, R.,Lozano, R.M.,Valverde, S.,Jimenez-Barbero, J.,Romero, A.,Gimenez-Gallego, G. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J.Biol.Chem., 285:11714-11729, 2010 Cited by PubMed: 20145243DOI: 10.1074/jbc.M109.064618 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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