3JS2

Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid

3JS2 の概要

• エントリーDOI: 10.2210/pdb3js2/pdb
• 分子名称: Basic fibroblast growth factor receptor 1, 5-(2-thienyl)nicotinic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: fibroblast growth factor, receptor tyrosine kinase, inhibitor, thienyl nicotinic acid, alternative splicing, atp-binding, chromosomal rearrangement, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73053.61

構造登録者

Bae, J.H.,Ravindranathan, K.P.,Mandiyan, V.,Ekkati, A.R.,Schlessinger, J.,Jorgensen, W.L. (登録日: 2009-09-09, 公開日: 2010-02-23, 最終更新日: 2023-09-20)

• 主引用文献: Ravindranathan, K.P.,Mandiyan, V.,Ekkati, A.R.,Bae, J.H.,Schlessinger, J.,Jorgensen, W.L.; Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening; J.Med.Chem., 53:1662-1672, 2010; PubMed: 20121196; DOI: 10.1021/jm901386e

実験手法

X-RAY DIFFRACTION (2.2 Å)