3JQ4

The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin

Summary for 3JQ4

• Entry DOI: 10.2210/pdb3jq4/pdb
• Related: 1NKW
• Descriptor: 23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide (3 entities in total)
• Functional Keywords: ribosome structure, antibiotics, lankacidin, lankamycin, protein synthesis, inhibitors, synergism, macrolide, rna
• Biological source: Deinococcus radiodurans; More
• Total number of polymer chains: 2
• Total formula weight: 971894.31

Authors

Auerbach-Nevo, T.,Mermershtain, I.,Davidovich, C.,Bashan, A.,Rozenberg, H.,Yonath, A. (deposition date: 2009-09-06, release date: 2010-09-08, Last modification date: 2023-11-01)

• Primary citation: Auerbach, T.,Mermershtain, I.,Davidovich, C.,Bashan, A.,Belousoff, M.,Wekselman, I.,Zimmerman, E.,Xiong, L.,Klepacki, D.,Arakawa, K.,Kinashi, H.,Mankin, A.S.,Yonath, A.; The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics; Proc.Natl.Acad.Sci.USA, 107:1983-1988, 2010; PubMed: 20080686; DOI: 10.1073/pnas.0914100107

Experimental method

X-RAY DIFFRACTION (3.52 Å)