3JPV
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand
3JPV の概要
エントリーDOI | 10.2210/pdb3jpv/pdb |
分子名称 | Proto-oncogene serine/threonine-protein kinase Pim-1, Peptide (PIMTIDE) ARKRRRHPSGPPTA, 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde, ... (4 entities in total) |
機能のキーワード | oncogene, kinase, serine-threonine, pim1, pyrrolo[2, 3-a]carbazole, structural genomics consortium, sgc, alternative initiation, atp-binding, cell membrane, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, transferase - transferase inhibitor complex, transferase / transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 37417.60 |
構造登録者 | Filippakopoulos, P.,Bullock, A.N.,Fedorov, O.,Akue-Gedu, R.,Rossignol, E.,Azzaro, S.,Bain, J.,Cohen, P.,Prudhomme, M.,Moreau, P.,Amizon, F.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-09-04, 公開日: 2009-10-27, 最終更新日: 2023-09-06) |
主引用文献 | Akue-Gedu, R.,Rossignol, E.,Azzaro, S.,Knapp, S.,Filippakopoulos, P.,Bullock, A.N.,Bain, J.,Cohen, P.,Prudhomme, M.,Anizon, F.,Moreau, P. Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors. J.Med.Chem., 52:6369-6381, 2009 Cited by PubMed: 19788246DOI: 10.1021/jm901018f 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.35 Å) |
構造検証レポート
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