3JPN
Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-dichloro methylene triphosphate
Summary for 3JPN
Entry DOI | 10.2210/pdb3jpn/pdb |
Related | 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT |
Descriptor | DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... (8 entities in total) |
Functional Keywords | dna polymerase, transferase, stereoselectivity, halogenated analogs, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P06746 |
Total number of polymer chains | 4 |
Total formula weight | 48321.15 |
Authors | Batra, V.K.,Upton, J.,Kashmerov, B.,Beard, W.A.,Wilson, S.H.,Goodman, M.F.,McKenna, C.E. (deposition date: 2009-09-04, release date: 2010-06-02, Last modification date: 2023-09-06) |
Primary citation | Batra, V.K.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.,Kashemirov, B.A.,Upton, T.G.,Goodman, M.F.,McKenna, C.E. Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. J.Am.Chem.Soc., 132:7617-7625, 2010 Cited by PubMed: 20465217DOI: 10.1021/ja909370k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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