Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy

Summary for 3J5R

Related3J5P 3J5Q
EMDB information5777 5776 5778
DescriptorTransient receptor potential cation channel subfamily V member 1 (1 entity in total)
Functional Keywordstrpv1 channel, capsaicin, transport protein
Biological sourceRattus norvegicus (rat)
Total number of polymer chains4
Total molecular weight272968.62
Liao, M.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2013-10-28, release date: 2013-12-04, Last modification date: 2018-07-18)
Primary citation
Cao, E.,Liao, M.,Cheng, Y.,Julius, D.
TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504:113-118, 2013
PubMed: 24305161 (PDB entries with the same primary citation)
DOI: 10.1038/nature12823
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers821.2%26.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j5r
no rotation
Molmil generated image of 3j5r
rotated about x axis by 90°
Molmil generated image of 3j5r
rotated about y axis by 90°
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