An improved model of the human apoptosome

Replaces:  3IZA

Summary for 3J2T

EMDB information5186
DescriptorApoptotic protease-activating factor 1, Cytochrome c, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordsapoptosis protease activating factor-1, apaf-1, cytochrome c, apoptosis
Biological sourceHomo sapiens (human)
Total number of polymer chains14
Total molecular weight1097704.1
Yuan, S.,Topf, M.,Akey, C.W. (deposition date: 2012-12-23, release date: 2013-04-10, Last modification date: 2018-07-18)
Primary citation
Yuan, S.,Topf, M.,Reubold, T.F.,Eschenburg, S.,Akey, C.W.
Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52:2319-2327, 2013
PubMed: 23521171 (PDB entries with the same primary citation)
DOI: 10.1021/bi301721g
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers162.1%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j2t
no rotation
Molmil generated image of 3j2t
rotated about x axis by 90°
Molmil generated image of 3j2t
rotated about y axis by 90°