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3IYV

Clathrin D6 coat as full-length Triskelions

3IYV の概要
エントリーDOI10.2210/pdb3iyv/pdb
関連するPDBエントリー1XI4 1XI5
EMDBエントリー5119 5120
分子名称Clathrin heavy chain, Clathrin light chain A (2 entities in total)
機能のキーワードclathrin, alpha-zig-zag, beta-propeller, endocytosis-exocytosis complex, endocytosis/exocytosis
由来する生物種Bos taurus (cow)
詳細
タンパク質・核酸の鎖数18
化学式量合計1761160.03
構造登録者
Johnson, G.T.,Fotin, A.,Cheng, Y.,Sliz, P.,Grigorieff, N.,Harrison, S.C.,Kirchhausen, T.,Walz, T. (登録日: 2010-06-17, 公開日: 2010-07-21, 最終更新日: 2024-02-21)
主引用文献Fotin, A.,Cheng, Y.,Sliz, P.,Grigorieff, N.,Harrison, S.C.,Kirchhausen, T.,Walz, T.
Molecular model for a complete clathrin lattice from electron cryomicroscopy.
Nature, 432:573-579, 2004
Cited by
PubMed Abstract: Clathrin-coated vesicles are important vehicles of membrane traffic in cells. We report the structure of a clathrin lattice at subnanometre resolution, obtained from electron cryomicroscopy of coats assembled in vitro. We trace most of the 1,675-residue clathrin heavy chain by fitting known crystal structures of two segments, and homology models of the rest, into the electron microscopy density map. We also define the position of the central helical segment of the light chain. A helical tripod, the carboxy-terminal parts of three heavy chains, projects inward from the vertex of each three-legged clathrin triskelion, linking that vertex to 'ankles' of triskelions centred two vertices away. Analysis of coats with distinct diameters shows an invariant pattern of contacts in the neighbourhood of each vertex, with more variable interactions along the extended parts of the triskelion 'legs'. These invariant local interactions appear to stabilize the lattice, allowing assembly and uncoating to be controlled by events at a few specific sites.
PubMed: 15502812
DOI: 10.1038/nature03079
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (7.9 Å)
構造検証レポート
Validation report summary of 3iyv
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-16に公開中

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