3IWV
Crystal structure of Y116T mutant of 5-HYDROXYISOURATE HYDROLASE (TRP)
Summary for 3IWV
Entry DOI | 10.2210/pdb3iwv/pdb |
Related | 2H1X 2H6U 3IWU |
Descriptor | 5-hydroxyisourate hydrolase (2 entities in total) |
Functional Keywords | transthyretin, molecular evolution, uric acid degradation, thyroid hormones, hydrolase, peroxisome, purine metabolism |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 4 |
Total formula weight | 61766.62 |
Authors | Cendron, L.,Ramazzina, I.,Berni, R.,Percudani, R.,Zanotti, G. (deposition date: 2009-09-03, release date: 2010-09-01, Last modification date: 2023-11-01) |
Primary citation | Cendron, L.,Ramazzina, I.,Percudani, R.,Rasore, C.,Zanotti, G.,Berni, R. Probing the evolution of hydroxyisourate hydrolase into transthyretin through active-site redesign. J.Mol.Biol., 409:504-512, 2011 Cited by PubMed: 21515285DOI: 10.1016/j.jmb.2011.04.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
Download full validation report