3IW5

Human p38 MAP Kinase in Complex with an Indole Derivative

3IW5 の概要

• エントリーDOI: 10.2210/pdb3iw5/pdb
• 関連するPDBエントリー: 3IW6 3IW7 3IW8
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, ... (4 entities in total)
• 機能のキーワード: dfg-out, type-i, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42375.28

構造登録者

Gruetter, C.,Simard, J.R.,Rauh, D. (登録日: 2009-09-02, 公開日: 2009-11-17, 最終更新日: 2023-11-01)

• 主引用文献: Simard, J.R.,Gruetter, C.,Pawar, V.,Aust, B.,Wolf, A.,Rabiller, M.,Wulfert, S.,Robubi, A.,Kluter, S.,Ottmann, C.,Rauh, D.; High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha; J.Am.Chem.Soc., 131:18478-18488, 2009; PubMed: 19950957; DOI: 10.1021/ja907795q

実験手法

X-RAY DIFFRACTION (2.5 Å)