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3IW4

Crystal structure of PKC alpha in complex with NVP-AEB071

Summary for 3IW4
Entry DOI10.2210/pdb3iw4/pdb
DescriptorProtein kinase C alpha type, 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione (3 entities in total)
Functional Keywordskinase, atp-binding, cell membrane, membrane, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, serine/threonine-protein kinase, transferase, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P17252
Total number of polymer chains3
Total formula weight126029.60
Authors
Stark, W.,Rummel, G.,Strauss, A.,Cowan-Jacob, S.W. (deposition date: 2009-09-02, release date: 2009-11-03, Last modification date: 2021-11-10)
Primary citationWagner, J.,von Matt, P.,Sedrani, R.,Albert, R.,Cooke, N.,Ehrhardt, C.,Geiser, M.,Rummel, G.,Stark, W.,Strauss, A.,Cowan-Jacob, S.W.,Beerli, C.,Weckbecker, G.,Evenou, J.P.,Zenke, G.,Cottens, S.
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
J.Med.Chem., 52:6193-6196, 2009
Cited by
PubMed: 19827831
DOI: 10.1021/jm901108b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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