3IW4
Crystal structure of PKC alpha in complex with NVP-AEB071
Summary for 3IW4
Entry DOI | 10.2210/pdb3iw4/pdb |
Descriptor | Protein kinase C alpha type, 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione (3 entities in total) |
Functional Keywords | kinase, atp-binding, cell membrane, membrane, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, serine/threonine-protein kinase, transferase, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P17252 |
Total number of polymer chains | 3 |
Total formula weight | 126029.60 |
Authors | Stark, W.,Rummel, G.,Strauss, A.,Cowan-Jacob, S.W. (deposition date: 2009-09-02, release date: 2009-11-03, Last modification date: 2021-11-10) |
Primary citation | Wagner, J.,von Matt, P.,Sedrani, R.,Albert, R.,Cooke, N.,Ehrhardt, C.,Geiser, M.,Rummel, G.,Stark, W.,Strauss, A.,Cowan-Jacob, S.W.,Beerli, C.,Weckbecker, G.,Evenou, J.P.,Zenke, G.,Cottens, S. Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes J.Med.Chem., 52:6193-6196, 2009 Cited by PubMed: 19827831DOI: 10.1021/jm901108b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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