3IUC

Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP

Summary for 3IUC

• Entry DOI: 10.2210/pdb3iuc/pdb
• Descriptor: Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa), ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: helix, structural genomics, structural genomics consortium, sgc, atp-binding, nucleotide-binding, stress response, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 91422.62

Authors

Wisniewska, M.,Karlberg, T.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotyenova, T.,Kotzch, A.,Kraulis, P.,Markova, N.,Moche, M.,Nielsen, T.K.,Nordlund, P.,Nyman, T.,Persson, C.,Roos, A.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-08-31, release date: 2009-09-22, Last modification date: 2023-11-01)

• Primary citation: Wisniewska, M.,Karlberg, T.,Lehtio, L.,Johansson, I.,Kotenyova, T.,Moche, M.,Schuler, H.; Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78; Plos One, 5:e8625-e8625, 2010; PubMed: 20072699; DOI: 10.1371/journal.pone.0008625

Experimental method

X-RAY DIFFRACTION (2.4 Å)