3IUC

Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP

3IUC の概要

• エントリーDOI: 10.2210/pdb3iuc/pdb
• 分子名称: Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa), ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: helix, structural genomics, structural genomics consortium, sgc, atp-binding, nucleotide-binding, stress response, chaperone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 91422.62

構造登録者

Wisniewska, M.,Karlberg, T.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotyenova, T.,Kotzch, A.,Kraulis, P.,Markova, N.,Moche, M.,Nielsen, T.K.,Nordlund, P.,Nyman, T.,Persson, C.,Roos, A.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (登録日: 2009-08-31, 公開日: 2009-09-22, 最終更新日: 2023-11-01)

• 主引用文献: Wisniewska, M.,Karlberg, T.,Lehtio, L.,Johansson, I.,Kotenyova, T.,Moche, M.,Schuler, H.; Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78; Plos One, 5:e8625-e8625, 2010; PubMed: 20072699; DOI: 10.1371/journal.pone.0008625

実験手法

X-RAY DIFFRACTION (2.4 Å)