3IT7

Crystal Structure of the LasA virulence factor from Pseudomonas aeruginosa

Summary for 3IT7

• Entry DOI: 10.2210/pdb3it7/pdb
• Related: 3IT5
• Descriptor: Protease lasA, ZINC ION, L(+)-TARTARIC ACID, ... (5 entities in total)
• Functional Keywords: metallopeptidase, m23, beta-protein, cell membrane, cell outer membrane, hydrolase, membrane, metal-binding, metalloprotease, protease, zymogen
• Biological source: Pseudomonas aeruginosa
• Cellular location: Secreted : P14789
• Total number of polymer chains: 2
• Total formula weight: 40669.08

Authors

Spencer, J.,Murphy, L.M.,Conners, R.,Sessions, R.B.,Gamblin, S.J. (deposition date: 2009-08-27, release date: 2009-11-17, Last modification date: 2017-11-01)

• Primary citation: Spencer, J.,Murphy, L.M.,Conners, R.,Sessions, R.B.,Gamblin, S.J.; Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.; J.Mol.Biol., 396:908-923, 2010; PubMed: 20026068; DOI: 10.1016/j.jmb.2009.12.021

Experimental method

X-RAY DIFFRACTION (2.14 Å)