3IQJ

Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)

3IQJ の概要

• エントリーDOI: 10.2210/pdb3iqj/pdb
• 関連するPDBエントリー: 3CU8 3IQU 3IQV
• 分子名称: 14-3-3 protein sigma, 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: signal transduction, nucleus, phosphoprotein, secreted, atp-binding, disease mutation, kinase, metal-binding, nucleotide-binding, phorbol-ester binding, proto-oncogene, serine/threonine-protein kinase, transferase, zinc-finger, protein binding, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P31947 P04049
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27875.46

構造登録者

Ottmann, C.,Weyand, M. (登録日: 2009-08-20, 公開日: 2010-09-01, 最終更新日: 2023-11-22)

• 主引用文献: Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C.; Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.; Mol.Cell.Biol., 30:4698-4711, 2010; PubMed: 20679480; DOI: 10.1128/MCB.01636-09

実験手法

X-RAY DIFFRACTION (1.15 Å)