3IPX
X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor
Summary for 3IPX
Entry DOI | 10.2210/pdb3ipx/pdb |
Related | 3IPY |
Descriptor | Deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, 2'-deoxy-5-fluorocytidine, ... (5 entities in total) |
Functional Keywords | human deoxycytidine kinase, atp-binding, kinase, nucleotide-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 1 |
Total formula weight | 29324.08 |
Authors | Tari, L.W.,Swanson, R.V.,Hunter, M.,Hoffman, I.,Stouch, T.R.,Carson, K.G. (deposition date: 2009-08-18, release date: 2010-08-18, Last modification date: 2023-09-06) |
Primary citation | Jessop, T.C.,Tarver, J.E.,Carlsen, M.,Xu, A.,Healy, J.P.,Heim-Riether, A.,Fu, Q.,Taylor, J.A.,Augeri, D.J.,Shen, M.,Stouch, T.R.,Swanson, R.V.,Tari, L.W.,Hunter, M.,Hoffman, I.,Keyes, P.E.,Yu, X.C.,Miranda, M.,Liu, Q.,Swaffield, J.C.,David Kimball, S.,Nouraldeen, A.,Wilson, A.G.,Foushee, A.M.,Jhaver, K.,Finch, R.,Anderson, S.,Oravecz, T.,Carson, K.G. Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg.Med.Chem.Lett., 19:6784-6787, 2009 Cited by PubMed: 19836232DOI: 10.1016/j.bmcl.2009.09.081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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