3IPQ

X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha

3IPQ の概要

• エントリーDOI: 10.2210/pdb3ipq/pdb
• 関連するPDBエントリー: 3IPS 3IPU
• 分子名称: Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid, ... (5 entities in total)
• 機能のキーワード: nuclear receptor, lxr homodimer, lxr signaling, alternative splicing, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, chromosomal rearrangement, isopeptide bond, phosphoprotein, proto-oncogene, transferase, ubl conjugation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Potential): Q13133; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36350.67

構造登録者

Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wijnands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennet, D.J.,McGuire, R.,Uitdehaag, J.C.M. (登録日: 2009-08-18, 公開日: 2010-06-02, 最終更新日: 2024-04-03)

• 主引用文献: Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wynands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennett, D.J.,McGuire, R.,Uitdehaag, J.C.; X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.; J.Mol.Biol., 399:120-132, 2010; PubMed: 20382159; DOI: 10.1016/j.jmb.2010.04.005

実験手法

X-RAY DIFFRACTION (2 Å)