3IPB
Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (11 carbon linker).
Summary for 3IPB
Entry DOI | 10.2210/pdb3ipb/pdb |
Related | 3IPE 3IPG |
Descriptor | Transthyretin, 2,2'-{undecane-1,11-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid (3 entities in total) |
Functional Keywords | amyloid, inhibitor, palindrome, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, secreted, thyroid hormone, transport |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 29051.76 |
Authors | Kolstoe, S.E.,Wood, S.P.,Pepys, M.B. (deposition date: 2009-08-17, release date: 2010-11-17, Last modification date: 2024-02-21) |
Primary citation | Kolstoe, S.E.,Mangione, P.P.,Bellotti, V.,Taylor, G.W.,Tennent, G.A.,Deroo, S.,Morrison, A.J.,Cobb, A.J.,Coyne, A.,McCammon, M.G.,Warner, T.D.,Mitchell, J.,Gill, R.,Smith, M.D.,Ley, S.V.,Robinson, C.V.,Wood, S.P.,Pepys, M.B. Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc.Natl.Acad.Sci.USA, 107:20483-20488, 2010 Cited by PubMed: 21059958DOI: 10.1073/pnas.1008255107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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