3IN7

Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic

3IN7 の概要

• エントリーDOI: 10.2210/pdb3in7/pdb
• 関連するPDBエントリー: 2HUW 3C7I 3IMD 3IMJ 3IN8
• 関連するBIRD辞書のPRD_ID: PRD_000633
• 分子名称: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide (3 entities in total)
• 機能のキーワード: ligand preorganization, peptide mimics, golgi apparatus, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, signaling protein-pseudopeptide ligand complex, signaling protein-peptide complex, signaling protein/peptide
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P62993
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28630.01

構造登録者

Clements, J.H. (登録日: 2009-08-11, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Delorbe, J.E.,Clements, J.H.,Teresk, M.G.,Benfield, A.P.,Plake, H.R.,Millspaugh, L.E.,Martin, S.F.; Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization.; J.Am.Chem.Soc., 131:16758-16770, 2009; PubMed: 19886660; DOI: 10.1021/ja904698q

実験手法

X-RAY DIFFRACTION (2 Å)