3IN3
Bace1 with Compound 30
Summary for 3IN3
Entry DOI | 10.2210/pdb3in3/pdb |
Related | 3IN4 |
Descriptor | Beta-secretase 1, (5S)-2-amino-3-methyl-5-pyridin-4-yl-5-(3-pyridin-3-ylphenyl)-3,5-dihydro-4H-imidazol-4-one (3 entities in total) |
Functional Keywords | bace1, inhibitor, alternative splicing, aspartyl protease, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46784.36 |
Authors | Olland, A.M. (deposition date: 2009-08-11, release date: 2010-01-19, Last modification date: 2011-07-13) |
Primary citation | Malamas, M.S.,Barnes, K.,Johnson, M.,Hui, Y.,Zhou, P.,Turner, J.,Hu, Y.,Wagner, E.,Fan, K.,Chopra, R.,Olland, A.,Bard, J.,Pangalos, M.,Reinhart, P.,Robichaud, A.J. Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors. Bioorg.Med.Chem., 18:630-639, 2010 Cited by PubMed: 20045648DOI: 10.1016/j.bmc.2009.12.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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