3IL8

CRYSTAL STRUCTURE OF INTERLEUKIN 8: SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY

3IL8 の概要

• エントリーDOI: 10.2210/pdb3il8/pdb
• 分子名称: INTERLEUKIN-8 (2 entities in total)
• 機能のキーワード: cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P10145
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8401.81

構造登録者

Baldwin, E.T.,Weber, I.T.,St Charles, R.,Xuan, J.-C.,Appella, E.,Yamada, M.,Matsushima, K.,Edwards, B.F.P.,Clore, G.M.,Gronenborn, A.M.,Wlodawer, A. (登録日: 1990-12-07, 公開日: 1992-10-15, 最終更新日: 2024-10-30)

主引用文献

Baldwin, E.T.,Weber, I.T.,St Charles, R.,Xuan, J.C.,Appella, E.,Yamada, M.,Matsushima, K.,Edwards, B.F.,Clore, G.M.,Gronenborn, A.M.,Wlodawer, A.
Crystal structure of interleukin 8: symbiosis of NMR and crystallography.
Proc.Natl.Acad.Sci.USA, 88:502-506, 1991

PubMed Abstract: The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.

PubMed: 1988949
DOI: 10.1073/pnas.88.2.502

実験手法

X-RAY DIFFRACTION (2 Å)