3IL5

Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid

Summary for 3IL5

Entry DOI	10.2210/pdb3il5/pdb
Related	3IL3 3IL4 3IL6 3IL7 3IL9
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 3, 2-({[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl}amino)benzoic acid (3 entities in total)
Functional Keywords	fabh, fatty acid biosynthesis, antibiotic, acyltransferase, cytoplasm, lipid synthesis, multifunctional enzyme, transferase
Biological source	Enterococcus faecalis
Cellular location	Cytoplasm : Q820T1
Total number of polymer chains	4
Total formula weight	152475.28
Authors	Gajiwala, K.S.,Margosiak, S.,Lu, J.,Cortez, J.,Su, Y.,Nie, Z.,Appelt, K. (deposition date: 2009-08-06, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Gajiwala, K.S.,Margosiak, S.,Lu, J.,Cortez, J.,Su, Y.,Nie, Z.,Appelt, K. Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583:2939-2946, 2009 Cited by PubMed: 19665020 DOI: 10.1016/j.febslet.2009.08.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation