3IKA

Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002

3IKA の概要

• エントリーDOI: 10.2210/pdb3ika/pdb
• 関連するPDBエントリー: 2jit 2jiu 2jiv
• 分子名称: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide (3 entities in total)
• 機能のキーワード: egfr, t790m, wz4002, wz-4002, alternative splicing, atp-binding, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tumor suppressor, tyrosine-protein kinase, ubl conjugation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75820.06

構造登録者

Yun, C.-H.,Eck, M.J. (登録日: 2009-08-05, 公開日: 2010-01-12, 最終更新日: 2021-10-13)

• 主引用文献: Zhou, W.,Ercan, D.,Chen, L.,Yun, C.H.,Li, D.,Capelletti, M.,Cortot, A.B.,Chirieac, L.,Iacob, R.E.,Padera, R.,Engen, J.R.,Wong, K.K.,Eck, M.J.,Gray, N.S.,Janne, P.A.; Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.; Nature, 462:1070-1074, 2009; PubMed: 20033049; DOI: 10.1038/nature08622

実験手法

X-RAY DIFFRACTION (2.9 Å)