3IK3

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

Summary for 3IK3

• Entry DOI: 10.2210/pdb3ik3/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total)
• Functional Keywords: bcr-abl, cml, t315i, inhibitor, mutation, drug resistance, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm, cytoskeleton: P00520
• Total number of polymer chains: 2
• Total formula weight: 67573.16

Authors

Zhou, T. (deposition date: 2009-08-05, release date: 2009-11-03, Last modification date: 2023-09-06)

• Primary citation: O'Hare, T.,Shakespeare, W.C.,Zhu, X.,Eide, C.A.,Rivera, V.M.,Wang, F.,Adrian, L.T.,Zhou, T.,Huang, W.S.,Xu, Q.,Metcalf, C.A.,Tyner, J.W.,Loriaux, M.M.,Corbin, A.S.,Wardwell, S.,Ning, Y.,Keats, J.A.,Wang, Y.,Sundaramoorthi, R.,Thomas, M.,Zhou, D.,Snodgrass, J.,Commodore, L.,Sawyer, T.K.,Dalgarno, D.C.,Deininger, M.W.,Druker, B.J.,Clackson, T.; AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.; Cancer Cell, 16:401-412, 2009; PubMed: 19878872; DOI: 10.1016/j.ccr.2009.09.028

Experimental method

X-RAY DIFFRACTION (1.9 Å)