3IIT

Factor XA in complex with a cis-1,2-diaminocyclohexane derivative

Summary for 3IIT

Entry DOI	10.2210/pdb3iit/pdb
Related	1v3x 1wu1 2EI6 2EI7 2EI8 2d1j
Descriptor	Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ... (5 entities in total)
Functional Keywords	glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, blood coagulation, cleavage on pair of basic residues, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, hydroxylation, protease, secreted, zymogen
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00742 P00742
Total number of polymer chains	2
Total formula weight	32814.75
Authors	Suzuki, M. (deposition date: 2009-08-03, release date: 2010-08-04, Last modification date: 2023-11-01)
Primary citation	Yoshikawa, K.,Kobayashi, S.,Nakamoto, Y.,Haginoya, N.,Komoriya, S.,Yoshino, T.,Nagata, T.,Mochizuki, A.,Watanabe, K.,Suzuki, M.,Kanno, H.,Ohta, T. Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties. Bioorg.Med.Chem., 17:8221-8233, 2009 Cited by PubMed: 19900814 DOI: 10.1016/j.bmc.2009.10.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation