3IIA

Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase

3IIA の概要

• エントリーDOI: 10.2210/pdb3iia/pdb
• 関連するPDBエントリー: 1NE4 1NE6 1RGS 1RL3 3FHI
• 分子名称: cAMP-dependent protein kinase type I-alpha regulatory subunit, GLYCEROL (3 entities in total)
• 機能のキーワード: protein kinase a, cyclic amp, ria subunit, camp, camp-binding, disulfide bond, nucleotide-binding, phosphoprotein, transferase
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Cell membrane : P00514
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17431.66

構造登録者

Sjoberg, T.J.,Kim, C.,Kornev, A.P.,Taylor, S.S. (登録日: 2009-07-31, 公開日: 2010-08-11, 最終更新日: 2023-09-06)

• 主引用文献: Badireddy, S.,Yunfeng, G.,Ritchie, M.,Akamine, P.,Wu, J.,Kim, C.W.,Taylor, S.S.,Qingsong, L.,Swaminathan, K.,Anand, G.S.; Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.; Mol.Cell Proteomics, 10:M110.004390-M110.004390, 2011; PubMed: 21081668; DOI: 10.1074/mcp.M110.004390

実験手法

X-RAY DIFFRACTION (2.7 Å)