3II5
The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor
Summary for 3II5
Entry DOI | 10.2210/pdb3ii5/pdb |
Related | 1UWH |
Descriptor | B-Raf proto-oncogene serine/threonine-protein kinase, N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | b-raf, kinase, protein-inhibitor complex, acetylation, atp-binding, cardiomyopathy, cytoplasm, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71542.16 |
Authors | Xu, W.,Breger, D.,Torres, N.,Dutia, M.,Powell, D.,Ciszewski, G. (deposition date: 2009-07-31, release date: 2009-11-10, Last modification date: 2024-02-21) |
Primary citation | Berger, D.M.,Torres, N.,Dutia, M.,Powell, D.,Ciszewski, G.,Gopalsamy, A.,Levin, J.I.,Kim, K.H.,Xu, W.,Wilhelm, J.,Hu, Y.,Collins, K.,Feldberg, L.,Kim, S.,Frommer, E.,Wojciechowicz, D.,Mallon, R. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg.Med.Chem.Lett., 19:6519-6523, 2009 Cited by PubMed: 19864136DOI: 10.1016/j.bmcl.2009.10.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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