3IGU

Crystal structure of human alpha-N-acetylgalactosaminidase, covalent intermediate

3IGU の概要

• エントリーDOI: 10.2210/pdb3igu/pdb
• 関連するPDBエントリー: 3H53 3H54 3H55
• 分子名称: Alpha-N-acetylgalactosaminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, schindler disease, kanzaki disease, disease mutation, disulfide bond, epilepsy, hydrolase, lysosome, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P17050
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96206.42

構造登録者

Clark, N.E.,Garman, S.C. (登録日: 2009-07-28, 公開日: 2009-10-20, 最終更新日: 2023-09-06)

• 主引用文献: Clark, N.E.,Garman, S.C.; The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases; J.Mol.Biol., 393:435-447, 2009; PubMed: 19683538; DOI: 10.1016/j.jmb.2009.08.021

実験手法

X-RAY DIFFRACTION (2.15 Å)