3IG1
HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
Summary for 3IG1
Entry DOI | 10.2210/pdb3ig1/pdb |
Descriptor | HIV-1 Reverse Transcriptase p66 subunit, HIV-1 Reverse Transcriptase p51 subunit, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, ... (5 entities in total) |
Functional Keywords | rnase h inhibitor, protein-inhibitor complex, structure-based drug design, tropolones, tropylium ion, divalent cation chelator, aids, dna-directed dna polymerase, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-binding, rna-directed dna polymerase, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114144.58 |
Authors | Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Arnold, E. (deposition date: 2009-07-27, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Bauman, J.D.,Das, K.,Dharia, C.,Clark, A.D.,Ryan, K.,Hickey, M.J.,Love, R.A.,Hughes, S.H.,Bergqvist, S.,Arnold, E. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure, 17:1625-1635, 2009 Cited by PubMed: 20004166DOI: 10.1016/j.str.2009.09.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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