3IFW
Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester.
Summary for 3IFW
Entry DOI | 10.2210/pdb3ifw/pdb |
Related | 2ETL |
Descriptor | Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin, METHYL 4-AMINOBUTANOATE, ... (4 entities in total) |
Functional Keywords | enzyme-suicide substrate complex, cytoplasm, disease mutation, glycoprotein, hydrolase, ligase, oxidation, polymorphism, protease, thiol protease, ubl conjugation pathway, isopeptide bond, nucleus, phosphoprotein, ubl conjugation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P09936 |
Total number of polymer chains | 2 |
Total formula weight | 33979.82 |
Authors | Das, C.,Boudreaux, D.,Maiti, T. (deposition date: 2009-07-26, release date: 2010-06-16, Last modification date: 2023-11-15) |
Primary citation | Boudreaux, D.A.,Maiti, T.K.,Davies, C.W.,Das, C. Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107:9117-9122, 2010 Cited by PubMed: 20439756DOI: 10.1073/pnas.0910870107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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