3IFW

Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester.

3IFW の概要

• エントリーDOI: 10.2210/pdb3ifw/pdb
• 関連するPDBエントリー: 2ETL
• 分子名称: Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin, METHYL 4-AMINOBUTANOATE, ... (4 entities in total)
• 機能のキーワード: enzyme-suicide substrate complex, cytoplasm, disease mutation, glycoprotein, hydrolase, ligase, oxidation, polymorphism, protease, thiol protease, ubl conjugation pathway, isopeptide bond, nucleus, phosphoprotein, ubl conjugation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P09936
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33979.82

構造登録者

Das, C.,Boudreaux, D.,Maiti, T. (登録日: 2009-07-26, 公開日: 2010-06-16, 最終更新日: 2023-11-15)

• 主引用文献: Boudreaux, D.A.,Maiti, T.K.,Davies, C.W.,Das, C.; Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation.; Proc.Natl.Acad.Sci.USA, 107:9117-9122, 2010; PubMed: 20439756; DOI: 10.1073/pnas.0910870107

実験手法

X-RAY DIFFRACTION (2.4 Å)