3IFV

Crystal structure of the Haloferax volcanii proliferating cell nuclear antigen

3IFV の概要

• エントリーDOI: 10.2210/pdb3ifv/pdb
• 分子名称: PCNA, SODIUM ION (3 entities in total)
• 機能のキーワード: processivity factor, sliding clamp, halophilic, replication
• 由来する生物種: Haloferax volcanii (Haloferax volcanii)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 80294.89

構造登録者

Winter, J.A.,Christofi, P.,Morroll, S.,Bunting, K.A. (登録日: 2009-07-26, 公開日: 2009-09-01, 最終更新日: 2023-11-01)

主引用文献

Winter, J.A.,Christofi, P.,Morroll, S.,Bunting, K.A.
The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation
Bmc Struct.Biol., 9:55-55, 2009

PubMed Abstract: The high intracellular salt concentration required to maintain a halophilic lifestyle poses challenges to haloarchaeal proteins that must stay soluble, stable and functional in this extreme environment. Proliferating cell nuclear antigen (PCNA) is a fundamental protein involved in maintaining genome integrity, with roles in both DNA replication and repair. To investigate the halophilic adaptation of such a key protein we have crystallised and solved the structure of Haloferax volcanii PCNA (HvPCNA) to a resolution of 2.0 A.

PubMed: 19698123
DOI: 10.1186/1472-6807-9-55

実験手法

X-RAY DIFFRACTION (2 Å)