3IEO

The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example

3IEO の概要

• エントリーDOI: 10.2210/pdb3ieo/pdb
• 関連するPDBエントリー: 3F8E
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, antiepilectic, disease mutation, lyase, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30128.07

構造登録者

Temperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T. (登録日: 2009-07-23, 公開日: 2010-01-26, 最終更新日: 2023-11-01)

• 主引用文献: Temperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T.; The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors; J.Med.Chem., 53:850-854, 2010; PubMed: 20028100; DOI: 10.1021/jm901524f

実験手法

X-RAY DIFFRACTION (2 Å)