3IDX

Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C222

3IDX の概要

• エントリーDOI: 10.2210/pdb3idx/pdb
• 関連するPDBエントリー: 3IDY
• 分子名称: HIV-1 HxBc2 gp120 core, Fab b13 heavy chain, Fab b13 light chain, ... (8 entities in total)
• 機能のキーワード: hiv-1, antibody, gp120, b13, envelope glycan protein, cd4-binding site, aids, apoptosis, cell membrane, cleavage on pair of basic residues, disulfide bond, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, viral immunoevasion, virion, immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 88069.21

構造登録者

Chen, L.,Kwon, Y.D.,Zhou, T.,Wu, X.,O'Dell, S.,Cavacini, L.,Hessell, A.J.,Pancera, M.,Tang, M.,Xu, L.,Yang, Z.Y.,Zhang, M.Y.,Arthos, J.,Burton, D.R.,Dimitrov, D.S.,Nabel, G.J.,Posner, M.,Sodroski, J.,Wyatt, R.,Mascola, J.R.,Kwong, P.D. (登録日: 2009-07-22, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Chen, L.,Do Kwon, Y.,Zhou, T.,Wu, X.,O'Dell, S.,Cavacini, L.,Hessell, A.J.,Pancera, M.,Tang, M.,Xu, L.,Yang, Z.Y.,Zhang, M.Y.,Arthos, J.,Burton, D.R.,Dimitrov, D.S.,Nabel, G.J.,Posner, M.R.,Sodroski, J.,Wyatt, R.,Mascola, J.R.,Kwong, P.D.; Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.; Science, 326:1123-1127, 2009; PubMed: 19965434; DOI: 10.1126/science.1175868

実験手法

X-RAY DIFFRACTION (2.5 Å)