3ICM

Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate, Mg2+ and 1-(2-Hydroxy-2,2-bis-phosphono-ethyl)-3-phenyl-pyridinium

3ICM の概要

• エントリーDOI: 10.2210/pdb3icm/pdb
• 関連するPDBエントリー: 1YHK 1YHL 1YKM 3IBA 3ICK 3ICN 3ICZ 3ID0
• 分子名称: Farnesyl pyrophosphate synthase, 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: farnesyl diphosphate synthase, fpps, bisphosphonate, zoledronate, risedronate, minodronate, chagas disease, isoprene biosynthesis, transferase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42000.61

構造登録者

Amzel, L.M.,Huang, C.H.,Gabelli, S.B.,Oldfield, E. (登録日: 2009-07-17, 公開日: 2010-02-09, 最終更新日: 2024-02-21)

• 主引用文献: Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M.; Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.; Proteins, 78:888-899, 2010; PubMed: 19876942; DOI: 10.1002/prot.22614

実験手法

X-RAY DIFFRACTION (2.2 Å)