3IAD

Crystal structure of human phosphodiesterase 4D with bound allosteric modulator

3IAD の概要

• エントリーDOI: 10.2210/pdb3iad/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea, ZINC ION, ... (6 entities in total)
• 機能のキーワード: pde4d, allosteric modulatory, inhibitor, ucr2, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal-binding, phosphoprotein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Apical cell membrane : Q08499
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 177286.11

構造登録者

Staker, B.L.,Burgin Jr., A.B. (登録日: 2009-07-13, 公開日: 2010-01-05, 最終更新日: 2024-02-21)

• 主引用文献: Burgin, A.B.,Magnusson, O.T.,Singh, J.,Witte, P.,Staker, B.L.,Bjornsson, J.M.,Thorsteinsdottir, M.,Hrafnsdottir, S.,Hagen, T.,Kiselyov, A.S.,Stewart, L.J.,Gurney, M.E.; Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.; Nat.Biotechnol., 28:63-70, 2010; PubMed: 20037581; DOI: 10.1038/nbt.1598

実験手法

X-RAY DIFFRACTION (2.65 Å)