3IA6

X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist

3IA6 の概要

• エントリーDOI: 10.2210/pdb3ia6/pdb
• 関連するPDBエントリー: 2Q8S
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-3-{4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl}-2-(2H-1,2,3-triazol-2-yl)propanoic acid (3 entities in total)
• 機能のキーワード: protein-ligand complex, dual specificity, inhibitor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62826.99

構造登録者

Ohren, J.F. (登録日: 2009-07-13, 公開日: 2009-10-13, 最終更新日: 2023-09-06)

• 主引用文献: Casimiro-Garcia, A.,Bigge, C.F.,Davis, J.A.,Padalino, T.,Pulaski, J.,Ohren, J.F.,McConnell, P.,Kane, C.D.,Royer, L.J.,Stevens, K.A.,Auerbach, B.,Collard, W.,McGregor, C.,Song, K.; Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.; Bioorg.Med.Chem., 17:7113-7125, 2009; PubMed: 19783444; DOI: 10.1016/j.bmc.2009.09.001

実験手法

X-RAY DIFFRACTION (2.31 Å)