3I9M

Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR

3I9M の概要

• エントリーDOI: 10.2210/pdb3i9m/pdb
• 関連するPDBエントリー: 3I9J 3I9K 3I9L 3I9N
• 分子名称: ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (3 entities in total)
• 機能のキーワード: enzyme-analog complex, covalent reaction intermediate, alpha helices rich domain and alpha/beta domain, alternative splicing, diabetes mellitus, disulfide bond, glycoprotein, hydrolase, membrane, nad, polymorphism, receptor, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type II membrane protein: P28907
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61851.40

構造登録者

Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q. (登録日: 2009-07-12, 公開日: 2009-07-28, 最終更新日: 2023-11-01)

• 主引用文献: Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q.; Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase; J.Biol.Chem., 284:27637-27645, 2009; PubMed: 19640846; DOI: 10.1074/jbc.M109.031005

実験手法

X-RAY DIFFRACTION (1.75 Å)