3I97

B1 domain of human Neuropilin-1 bound with small molecule EG00229

3I97 の概要

• エントリーDOI: 10.2210/pdb3i97/pdb
• 分子名称: Neuropilin-1, (S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: neuropilin-1, drug, vegf, angiogenesis, neuropilin, alternative splicing, cell membrane, developmental protein, differentiation, disulfide bond, glycoprotein, heparan sulfate, membrane, neurogenesis, phosphoprotein, polymorphism, proteoglycan, receptor, secreted, transmembrane, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: O14786
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36921.82

構造登録者

Allerston, C.K.,Djordjevic, S. (登録日: 2009-07-10, 公開日: 2010-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Jarvis, A.,Allerston, C.K.,Jia, H.,Herzog, B.,Garza-Garcia, A.,Winfield, N.,Ellard, K.,Aqil, R.,Lynch, R.,Chapman, C.,Hartzoulakis, B.,Nally, J.,Stewart, M.,Cheng, L.,Menon, M.,Tickner, M.,Djordjevic, S.,Driscoll, P.C.,Zachary, I.,Selwood, D.L.; Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.; J.Med.Chem., 53:2215-2226, 2010; PubMed: 20151671; DOI: 10.1021/jm901755g

実験手法

X-RAY DIFFRACTION (2.9 Å)