3I8W
Crystal structure of a metallacarborane inhibitor bound to HIV protease
Summary for 3I8W
| Entry DOI | 10.2210/pdb3i8w/pdb |
| Related | 1ZTZ |
| Descriptor | Protease, COBALT BIS(1,2-DICARBOLLIDE), CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | inhibitor, cobalt bis(1, 2-dicarbollide), viral resistance, aspartic protease, aids, aspartyl protease, capsid maturation, capsid protein, cell membrane, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Human immunodeficiency virus type 1 |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
| Total number of polymer chains | 1 |
| Total formula weight | 11256.10 |
| Authors | Rezacova, P. (deposition date: 2009-07-10, release date: 2009-12-01, Last modification date: 2023-09-06) |
| Primary citation | Pokorna, J.,Brynda, J.,Cigler, P.,Fanfrlik, J.,Sieglova, I.,Oberwinkler, H.,Hobza, P.,Kral, V.,Konvalinka, J. Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes J.Med.Chem., 52:7132-7141, 2009 Cited by PubMed: 19874035DOI: 10.1021/jm9011388 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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